![]() Its major function is to catalyze disulfide bond formation in newly synthesized proteins and, importantly, high concentrations of Ca 2+ augment this activity. PDI is an abundant and versatile redox enzyme that has oxidase, reductase and isomerase activity and interacts with a variety of substrates and is widely distributed in the ER lumen. The C-terminus of the protein contains numerous pairs of acidic residues that form the low affinity, high capacity Ca 2+ binding sites. PDI is a 58-kDa Ca 2+-binding chaperone that binds 19 mol of Ca 2+ per mol of protein with low affinity ( K d = 2–5 mM). During protein folding, PDI catalyzes the formation of native disulfide bonds and disulfide bond rearrangement. It comprises approximately 0.8% of total cellular protein and attains near millimolar concentrations in the ER lumen of some tissues. PDI is a ubiquitously expressed multifunctional protein found in the ER. Michalak, in Encyclopedia of Biological Chemistry (Second Edition), 2013 PDI Please wait 3 to 5 days for the funds to clear and post to your account.J. If approved, you’ll be automatically refunded on your original payment method. ![]() We will notify you once we’ve received and inspected your return, and let you know if the refund was approved or not. ![]() Please inspect your order upon delivery and contact us immediately if the item is defective, damaged or not as described, so that we can evaluate and promptly resolve the issue. You can always contact customer support with questions regarding your purchase or the status of your return by calling us at +1 (888) 737-5654 or emailing us at Customer satisfaction is our top priority. Please do not ship your returns to us until after we have approved your return and provided you with postage. ![]()
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